M.S. Chemistry
Summary
Versatile Chemist works with different types of chemicals, compounds and materials. Accomplished in performing tests, documenting results and writing papers. Well-organized and detail-oriented with good critical thinking problem solving and instrumentation care developed over the past four years. With two years of experience with analytical work, two years of peptide/bio-organic synthetic research, and four years of wet chemistry and organic synthesis, my experience and knowledge expands over several subsections of Chemistry and has taught me how to learn new skills pro????ciently. Three years of teaching various organic chemistry labs, I have also learned how to teach chemistry skills ef????ciently. My work at UCSC
was used to help with Covid-19 pathologies and I am honored to be part of a solution that has effected so many lives and I hope to continue to do work that makes a difference.
Work experience
2018-08 - 2020-06
Organic Chemistry PhD Student
UNIVERSITY OF CALIFORNIA, SANTA CRUZ; Santa Cruz, CA
PhD Organic Chemistry Graduate Student: my primary project involved synthesizing cyclic decapeptide-peptoid hybrids to examine which features caused certain macrocycles to have membrane passive permeability properties. The manuscript abstract for the paper to be published in JOC describing the research I collaborated on at UCSC:
Achieving drug-like cell permeability and oral bioavailability becomes increasingly dif????cult as molecular weight increases beyond ~600 Da. However, some cyclic peptides defy this trend, showing high passive permeability and oral bioavailability (BA) even with molecular weights exceeding 1000. Based on a series of published synthetic cyclic decapeptides with exceptionally high oral BA, we generated two libraries of derivatives in which we replaced pairs of N-methyl residues with N- alkylglycine (peptoid) residues and investigated their physico-chemical, ADME, and PK properties. NMR temperature shift experiments and hydrocarbon-water partition coef????cients indicated very different structure-property relationships depending on the location of the peptoid substitutions. Like the parent compounds, our cyclic peptomer derivatives had high passive membrane permeabilities, although our compounds had much lower oral BA due to high ef????ux and fast metabolic clearance. Oral dosing in the presence of both cytochrome P450 (ABT) and p-glyclprotein (GF) inhibitors had a strong synergistic effect, causing a dramatic increase in oral BA. Our studies indicate that the in vivo PK properties of >1000 MW cyclic peptide-peptoid hybrids can be predicted based on relatively simple physico-chemical measurements. These results, taken together with recent studies on smaller scaffolds, suggest that the effect of peptide-to-peptoid substitutions on ADME and PK properties, while scaffold-dependent, can be predicted and managed when efflux and metabolism are taken into account.
QC Chemist
CHEMDESIGN; Marinette, WI
As a QC Chemist, my primary duty was tomeasure and test the organic and inorganic products. Every day I began my 12-hour shift by calibrating, maintaining and operating the lab equipment and instrumentation. For new products, new analytical protocol procedures and standardized solutions had to be developed to analyze the physical and chemical properties. This included analytical methods for GC, HPLC, LCMS, MS, NMR, wet chemistry, and many more. Being a QC Chemist at ChemDesign is a high-pressure, independent, and mentally-challenging job since it requires going working 4:30-16:30 and 16:30-4:30 shifts every four days on your own. Learning how to thrive in a high-pressure and detail-oriented job showed me that I can do well in even the most challenging and demanding of jobs.
Undergraduate Research Assistant
DICKINSON COLLEGE; Carlisle, PA
1) Professor Samet, Analytical Chemistry: My Analytical Chemistry Research project with Professor Samet practiced matrix isolation with polymers using vacuums and FTIR. We ????rst used CaF2 glass plates then we used KBr glass plates and adding ????five layers of the polymer poly(4-vinypyridine-co-styrene) and vacuum pumping acetylene and argon gas onto the plate to see how well the polymer can absorb acetylene into the multiple layers. We studied the reaction at 16 K, 19 K, 21 K, 23 K, and 28 K. The different temperatures controlled how quickly the parent polymer disappeared. This research could be very important in creating new medicine and being applied to many nanotechnological techniques.
2) Professor Holden, Organo-Iron Chemistry: We were working with ferrocene with the original substituent of a carboxyl group. Then we attempted to change that substituent into a pyrimidine using an enaminone. We managed to changed the substituent into an amine, the second to ????nal step, but the ????nal step was not pure. This research is important because lots of people are trying to replace aromatic groups with ferrocene because they are better compounds for medical use.
Organic Chemistry Lab TA
DICKINSON COLLEGE; Carlisle, PA
Organic Chemistry, Part I & II: assist the professor by answering students’ questions, general explanation of the experiment, replace broken glassware, collect and return lab reports
Education
2018-09 - 2020-09
M.S. Organic Chemistry
UNIVERSITY OF CALIFORNIA, SANTA CRUZ
GPA: 4.0
Courses taken: Modern Organic Synthesis, Chemistry Seminar (six quarters), Teaching Chemistry, Modern Physical Organic, Spectroscopy Analytics, Advanced Biophysical Methods, and Independent Study
Courses TA’ed: Organic Chemistry I (3 quarters), Organic Chemistry II (2 quarters), Intermediate Organic Chemistry (1 quarter)
2013-09 - 2017-06
DICKINSON COLLEGE
Carlisle, PA
B.S. Chemistry
Major: Chemistry
Major GPA: 3.0
Relevant Science Courses: Biology of Behavior w/Lab, Psychology of Brain and Behavior w/Lab, Organic Chemistry I & II w/Lab, Modern Chemical Analysis w/Lab, Quantum Chemistry and Spectroscopy, Thermodynamics and Kinetics, Concepts of Inorganic Chemistry w/Lab, Advanced Organic Chemistry, Structure and Function of Biomolecules w/Lab, and Research
Minor: Math
Minor GPA: 3.2
Relevant Math Courses: Single and Multivariable Calculus, Introduction to Linear Algebra, Physics for the Life Sciences I & II w/Lab, Discrete Mathematics, and Integration and Infinite Series
Summary
Versatile Chemist works with different types of chemicals, compounds and materials. Accomplished in performing tests, documenting results and writing papers. Well-organized and detail-oriented with good critical thinking problem solving and instrumentation care developed over the past four years. With two years of experience with analytical work, two years of peptide/bio-organic synthetic research, and four years of wet chemistry and organic synthesis, my experience and knowledge expands over several subsections of Chemistry and has taught me how to learn new skills pro????ciently. Three years of teaching various organic chemistry labs, I have also learned how to teach chemistry skills ef????ciently. My work at UCSC
was used to help with Covid-19 pathologies and I am honored to be part of a solution that has effected so many lives and I hope to continue to do work that makes a difference.
Work experience
2018-08 - 2020-06
Organic Chemistry PhD Student
UNIVERSITY OF CALIFORNIA, SANTA CRUZ; Santa Cruz, CA
PhD Organic Chemistry Graduate Student: my primary project involved synthesizing cyclic decapeptide-peptoid hybrids to examine which features caused certain macrocycles to have membrane passive permeability properties. The manuscript abstract for the paper to be published in JOC describing the research I collaborated on at UCSC:
Achieving drug-like cell permeability and oral bioavailability becomes increasingly dif????cult as molecular weight increases beyond ~600 Da. However, some cyclic peptides defy this trend, showing high passive permeability and oral bioavailability (BA) even with molecular weights exceeding 1000. Based on a series of published synthetic cyclic decapeptides with exceptionally high oral BA, we generated two libraries of derivatives in which we replaced pairs of N-methyl residues with N- alkylglycine (peptoid) residues and investigated their physico-chemical, ADME, and PK properties. NMR temperature shift experiments and hydrocarbon-water partition coef????cients indicated very different structure-property relationships depending on the location of the peptoid substitutions. Like the parent compounds, our cyclic peptomer derivatives had high passive membrane permeabilities, although our compounds had much lower oral BA due to high ef????ux and fast metabolic clearance. Oral dosing in the presence of both cytochrome P450 (ABT) and p-glyclprotein (GF) inhibitors had a strong synergistic effect, causing a dramatic increase in oral BA. Our studies indicate that the in vivo PK properties of >1000 MW cyclic peptide-peptoid hybrids can be predicted based on relatively simple physico-chemical measurements. These results, taken together with recent studies on smaller scaffolds, suggest that the effect of peptide-to-peptoid substitutions on ADME and PK properties, while scaffold-dependent, can be predicted and managed when efflux and metabolism are taken into account.
QC Chemist
CHEMDESIGN; Marinette, WI
As a QC Chemist, my primary duty was tomeasure and test the organic and inorganic products. Every day I began my 12-hour shift by calibrating, maintaining and operating the lab equipment and instrumentation. For new products, new analytical protocol procedures and standardized solutions had to be developed to analyze the physical and chemical properties. This included analytical methods for GC, HPLC, LCMS, MS, NMR, wet chemistry, and many more. Being a QC Chemist at ChemDesign is a high-pressure, independent, and mentally-challenging job since it requires going working 4:30-16:30 and 16:30-4:30 shifts every four days on your own. Learning how to thrive in a high-pressure and detail-oriented job showed me that I can do well in even the most challenging and demanding of jobs.
Undergraduate Research Assistant
DICKINSON COLLEGE; Carlisle, PA
1) Professor Samet, Analytical Chemistry: My Analytical Chemistry Research project with Professor Samet practiced matrix isolation with polymers using vacuums and FTIR. We ????rst used CaF2 glass plates then we used KBr glass plates and adding ????five layers of the polymer poly(4-vinypyridine-co-styrene) and vacuum pumping acetylene and argon gas onto the plate to see how well the polymer can absorb acetylene into the multiple layers. We studied the reaction at 16 K, 19 K, 21 K, 23 K, and 28 K. The different temperatures controlled how quickly the parent polymer disappeared. This research could be very important in creating new medicine and being applied to many nanotechnological techniques.
2) Professor Holden, Organo-Iron Chemistry: We were working with ferrocene with the original substituent of a carboxyl group. Then we attempted to change that substituent into a pyrimidine using an enaminone. We managed to changed the substituent into an amine, the second to ????nal step, but the ????nal step was not pure. This research is important because lots of people are trying to replace aromatic groups with ferrocene because they are better compounds for medical use.
Organic Chemistry Lab TA
DICKINSON COLLEGE; Carlisle, PA
Organic Chemistry, Part I & II: assist the professor by answering students’ questions, general explanation of the experiment, replace broken glassware, collect and return lab reports
Education
2018-09 - 2020-09
M.S. Organic Chemistry
UNIVERSITY OF CALIFORNIA, SANTA CRUZ
GPA: 4.0
Courses taken: Modern Organic Synthesis, Chemistry Seminar (six quarters), Teaching Chemistry, Modern Physical Organic, Spectroscopy Analytics, Advanced Biophysical Methods, and Independent Study
Courses TA’ed: Organic Chemistry I (3 quarters), Organic Chemistry II (2 quarters), Intermediate Organic Chemistry (1 quarter)
2013-09 - 2017-06
DICKINSON COLLEGE
Carlisle, PA
B.S. Chemistry
Major: Chemistry
Major GPA: 3.0
Relevant Science Courses: Biology of Behavior w/Lab, Psychology of Brain and Behavior w/Lab, Organic Chemistry I & II w/Lab, Modern Chemical Analysis w/Lab, Quantum Chemistry and Spectroscopy, Thermodynamics and Kinetics, Concepts of Inorganic Chemistry w/Lab, Advanced Organic Chemistry, Structure and Function of Biomolecules w/Lab, and Research
Minor: Math
Minor GPA: 3.2
Relevant Math Courses: Single and Multivariable Calculus, Introduction to Linear Algebra, Physics for the Life Sciences I & II w/Lab, Discrete Mathematics, and Integration and Infinite Series